New Vegas is the newest edition to the Fallout franchise. It brings a whole new story line beyond that of Fallout 3, but with some familiar faces: The Enclave, The Brotherhood of Steel, Rad-scorpions, Death Claws, etc... The game is based in the post nuclear war wasteland of the Mojave Dessert. You are a courier that has been given a delivery to make, but have your journey cut short by a greedy casino owner, who shoots you in the head and steals the package: the Platinum Casino Chip. You must remember who you are and find the platinum chip, and along your journey you will encounter both resistance and support in the form of new allies and enemies, or vice-versa depending on your actions. The desert wasteland plays home to many new creatures and characters:
The NCR - The major military presence (You want to be their friends, maybe?)
The Legion- The major resistance presence (Bad Guys)
The Fiends- Name says it all (Sex, drugs, violence; it's what they live for!)
The Great Khans- Fairly intelligent (Mainly misunderstood.)
The Powder Gangers- Group of idiots with explosives (No real threat.)
Be careful when picking the path you want to follow: your actions affect everything in the game, whether you want them or not. You can quickly find yourself failing quest you didn't even know existed if you tick off the wrong people. A fun fact of the game: while there are probably 40 or so main quests, there are probably 100 to 150 side quests.
Along with the new characters, there are also many new creatures:
Ants- while introduced in Fallout 3, they are much more common in the Mojave.
Geckos- there are three kinds: regular, fire, and golden, each increasing in strength and damage.
Bloat Flies- yeah they're still here, but not a threat.
Cazadors (!!!)- the bloat flies' big brother, these things are a pain; they're hard to kill, very fast, and very poisonous (stock up on anti-venoms.)
Mantis- not a threat.
Bighorns- partially a domesticated animal, but there are some wild in the mountains and they will knock you around.
Death Claws (!!!!)- still the deadliest creature around, and now there are higher-level ones, such as a Mother, Alpha-Male, and others.
Don't worry, there are still Ghouls around and yes, they're still a pain.
All this doesn't even begin to scratch the surface.
In my book the best game of 2010, and yes, even better than COD: Black Ops.
But don't just take my word for it: get your own copy! They have already annouced plans for 5 DLC packs so definitely more to come...